When presented concomitantly with promethazine, the dose of barbiturates should be minimized by at the least one-50 percent, and the dose of narcotics need to be diminished by 1-quarter to 1-50 percent. Dosage needs to be individualized. Abnormal quantities of promethazine HCl relative to your narcotic may well produce restlessness https://wockusa.com/product-category/research-chemicals/