Environmental or self-antigens and homotypic interactions result in BCR and Toll-like receptor (TLR) signaling, amplifying the reaction of CLL cells to other signals in the microenvironment and rising the activation of anti-apoptotic and proliferation pathways.31,32 Genomic reports have identified recurrent mutations in genes regulating tumor cell-microenvironment interactions, which ... https://williamf218gnv6.blogozz.com/profile