There is a release of norepinephrine through the descending inhibitory bulbospinal neurons that binds to alpha-two-receptors in the dorsal horn to minimize afferent agony transmission and create analgesia. Consequently, prescription drugs like clonidine that target alpha-2 receptors can affect the transmission of suffering. Clonidine is distributed in breast milk; https://emilyt579tme5.wiki-cms.com/user