While in the LSD-sure crystal construction, the side chain in the lid residue L209EL2 sorts substantial hydrophobic contacts with each LSD and surrounding residues in TMs III, IV, and V (Figure 4C). When the lid moved apart to expose the binding pocket in simulation, several of such contacts broke. We https://rafaelidwnh.gigswiki.com/5652303/lsd_crystal_for_dummies