Pentobarbital will decrease the level or effect of prednisone by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. pentobarbital will decrease the level or effect of zonisamide by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Minor/Significance Unknown. pentobarbital will decrease the level or effect of bexarotene by affecting hepatic/intestinal enzy... https://bookmarkcork.com/story20977713/pentobarbital-vs-phenobarbital-una-panoramica